DSIP 5mg (10 Vials): Research Peptide Profile

DSIP 5mg*10vials: Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide that has been a subject of scientific interest since its discovery in 1977. This 10-vial kit provides 5mg of lyophilized DSIP per vial, designed for controlled research applications investigating sleep regulation, stress response, and neuroendocrine function.

What is DSIP?

DSIP is a nonapeptide (nine amino acids) with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu . It was originally isolated from the cerebral venous blood of rabbits during electrical stimulation of the thalamus, and its name derives from its first discovered physiological action: an EEG delta/spindles-inducing effect in recipient rabbits .

Key Identifiers:

• CAS Number: 62568-57-4 

• Molecular Formula: C₁₀H₁₆N₂O₅ 

• Purity: Typically ≥99% for research-grade material 

• Form: Lyophilized (freeze-dried) powder in glass vials 

Physical Properties:

• Store in a cool, dark, tightly sealed container 

• Refrigeration at 4°C recommended for stability 

• Shelf life: 24 months when properly stored 

Mechanism of Action

DSIP is synthesized in the hypothalamus and targets multiple sites in the brain, including regions within the brainstem . Unlike most peptides, DSIP can freely cross the blood-brain barrier and is readily absorbed without being denatured by enzymes .

Key Mechanisms:

• Neuronal Activation: DSIP microiontophoresis predominantly activates neurons in various brain regions, particularly in the dorsal hippocampus and ventral anterior thalamic nucleus .

• NMDA Receptor Interaction: DSIP’s effects on neuronal activity appear to be mediated through NMDA-receptors .

• Neurotransmitter Modulation: Research demonstrates DSIP’s capacity to modulate neurotransmitter levels, including serotonin (5-HT), glutamate, dopamine, and melatonin .

• Circadian Rhythm Influence: DSIP can influence and even generate circadian rhythms, affecting locomotor activity and the enzymatic activity of serotonin-N-acetyltransferase, a pineal enzyme with strong circadian rhythmicity .

Research Applications

Sleep Regulation

DSIP is primarily studied for its sleep-promoting properties. It has been demonstrated to promote sleep in rabbits, mice, rats, cats, and human beings . DSIP is described as a sleep-promoting substance rather than a sedative, with modulating effects on sleep and wake functions that show greater activity in circumstances where sleep is disturbed .

Stress and Neuroprotection

DSIP has demonstrated pronounced anti-stress effects, suppressing stress-induced immediate-early gene c-Fos expression in hypothalamus and limbic structures in rats . Recent research in PCPA-induced insomnia mouse models shows DSIP-CBBBP (a fusion peptide) demonstrates restorative effects on neurotransmitter imbalance, suggesting potential utility in sleep-related therapies .

Neuroendocrine Regulation

DSIP-like immunoreactivity (DSIP-LI) has been identified in hypothalamic and adjacent neurosecretory nuclei of various vertebrates, co-localizing with peptide hormones such as luliberin (gonadoliberin), oxytocin/neurophysin-1, corticotrophin-like intermediate lobe peptide (CLIP), ACTH, and MSH . DSIP-LI is also present in the gut, pancreas, and adrenal medulla.

Additional Considerations

• Half-Life: DSIP has a half-life in human plasma of between 7 and 8 minutes .

• Dose Response: DSIP exhibits a bell-shaped dose-response curve, with injection time dependence being a crucial characteristic of its activity .

• Potential Drug Interactions: Drugs inhibiting peptidases (such as ACE inhibitors) may interact with DSIP metabolism .(DSIP 5mg*10vials)

Safety & Regulatory Status

Research-Use Only

DSIP is not FDA-approved for any human therapeutic indication. This product is intended for in vitro and preclinical research use only.

Prohibited Status

• Sports: DSIP would likely fall under WADA’s prohibited substances category due to its neuroactive properties.

• Regulatory: Not listed for compounding or human therapeutic use.

Key Safety Considerations

• Unregulated Products: Research-grade material is unregulated and carries unknown contamination and dosing risks.

• Limited Human Data: While DSIP has been studied in humans, its long-term safety profile and efficacy remain subjects of ongoing investigation .

• Bell-Shaped Response: Dosage precision is critical; both insufficient and excessive doses may reduce effectiveness .

• Limited Efficacy Data: The hypothesis regarding DSIP as a sleep factor remains debated, with some researchers noting that its link to sleep has never been fully characterized due to lack of isolation of the DSIP gene and possible related receptor . Some studies have shown DSIP itself did not increase sleep in rats, while certain analogues did .

Reconstitution & Handling for Research

General Handling

• Solubility: Soluble in water.

• Storage: Store lyophilized powder at 4°C. Reconstituted solutions should be stored at -20°C and protected from repeated freeze-thaw cycles.

• Dilution: Reconstitute with sterile water or bacteriostatic water for injection.

Kit Contents

• 10 vials of lyophilized DSIP, 5mg each

Applications

DSIP is widely used as a research tool for:

• Sleep and circadian rhythm studies

• Stress and neuroprotection research

• Neurotransmitter and receptor investigations