CJC-1295 Without DAC (5mg) + Ipamorelin (5mg) Blend: A Synergistic Research Peptide Combination

CJC-1295 Without DAC 5mg + IPA 5mg: This 5mg/5mg blend combines two complementary peptides—CJC-1295 without DAC (a GHRH analog) and Ipamorelin (a GHRP)—designed for research into the modulation of the growth hormone (GH) axis(CJC-1295 Without DAC 5mg + IPA 5mg).

Overview of the Blend

This is a 1:1 fixed-ratio blend (5mg of each peptide per vial) formulated to investigate the synergistic effects of combined GHRH and GHRP pathways . It is a pre-blended formulation provided as a lyophilized powder for research purposes, eliminating the need to measure separate compounds .

Mechanism of Action

This combination targets GH release through two complementary pathways :

• CJC-1295 (without DAC) is a synthetic analog of Growth Hormone Releasing Hormone (GHRH) that binds to GHRH receptors on the pituitary. It functions as an amplifier, instructing the pituitary to produce more GH. The “without DAC” version has a short half-life (~30 minutes), which promotes a pulsatile release pattern that mimics the body’s natural GH rhythm .

• Ipamorelin is a selective growth hormone secretagogue receptor (GHS-R) agonist that mimics ghrelin. It acts as a trigger, stimulating the pituitary to release GH. Unlike earlier GHRPs, Ipamorelin is considered highly selective, with minimal effect on cortisol, prolactin, or ACTH .

• Synergy: The combination produces a supra-additive (greater than the sum of its parts) GH release, as the two compounds act on different receptors to both amplify and trigger the GH pulse .

Key Differences: With DAC vs. Without DAC

The “without DAC” designation is critical to the blend’s proposed mechanism:

• With DAC (Drug Affinity Complex): Bound to albumin, giving it a long half-life of 5.8 to 8.1 days . This creates a sustained, “bleed” of GHRH, which risks receptor desensitization over time .

• Without DAC: Has a short half-life of approximately 30 minutes . This produces a quick, sharp signal that mimics the body’s natural, physiological GH pulses and is theorized to maintain long-term receptor sensitivity .

Research Applications & Proposed Benefits

Based on its mechanism, this blend is investigated in research for:

• Body Composition: Supporting lean muscle development and fat metabolism .

• Recovery: Enhancing recovery from training or injury .

• Sleep: Improving deep, restorative sleep quality .

Reconstitution & Dosing Notes

For research protocols, the blend is typically reconstituted with bacteriostatic water. A common dose range is 100–200 mcg total peptide per injection, administered subcutaneously . Timing often involves dosing at night on an empty stomach to align with the natural GH pulse during sleep .