Gonadorelin Acetate 2mg: Research Peptide Profile

Gonadorelin acetate is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH) . As a specific agonist of the GnRH receptor, it stimulates the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland . This profile provides essential information for researchers working with this compound.

What is Gonadorelin Acetate?

Gonadorelin acetate is a synthetic peptide with a structure identical to the natural gonadotropin-releasing hormone in mammalian species . It functions as a GnRH receptor agonist, playing a central role in regulating the reproductive system by triggering the release of pituitary gonadotropins .

Key Identifiers:

• CAS Number: 34973-08-5 (acetate salt); 78308-49-3 (diacetate hydrate) 

• Molecular Formula: C₅₅H₇₅N₁₇O₁₃ · x(C₂H₄O₂) · y(H₂O) 

• Molecular Weight: 1182.29 + x(60.05) (free base); 1242.34 (acetate salt) 

• Purity: Typically >95% for research-grade material 

• Status: Research compound; no FDA-approved gonadorelin product is currently commercially available in the United States as of April 2026 

Mechanism of Action

Gonadorelin acetate acts as a specific agonist for the GnRH receptor . By binding to GnRH receptors in the anterior pituitary gland, it triggers a signaling cascade that promotes the secretion of LH and FSH . This process is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens .

Key Functions:

• Pituitary Stimulation: Stimulates synthesis and release of FSH and LH 

• Reproductive Regulation: Controls follicular growth, ovulation, corpus luteum maintenance (female), and spermatogenesis (male) 

• Short Half-Life: Its short half-life requires infusion pumps for clinical use 

Research Applications

In Vitro Studies

Research has demonstrated that Gonadorelin acetate treatment:

• Significantly inhibits the proliferation, migration, and multi-lineage differentiation potential of human endometrial stem cells (1μM; 72h) 

• Reduces GABA-activated currents and inhibits GABA-induced depolarization in rat spinal ganglion neurons (50µM; 30s-10min) 

In Vivo Research

In female ApcMin/+ mice, Gonadorelin acetate (150ng/mouse; subcutaneous injection; five days a week for three weeks):

• Significantly reduced small intestinal polyp multiplicity and size 

• Inhibited colon tumor formation 

Clinical Research Context

Pulsatile gonadorelin effectively stimulates LH and FSH in men with congenital hypogonadotropic hypogonadism . A 2020 meta-analysis pooling 420 men across eight comparative studies confirmed that pulsatile GnRH achieves earlier spermatogenesis onset versus combined gonadotropin therapy in this condition .

Regulatory Status and Legal Considerations

FDA Status

• No FDA-approved gonadorelin product is commercially available in the United States as of April 2026 

• The original branded product Factrel (gonadorelin hydrochloride injection, Wyeth) was withdrawn from the market; no active NDA or ANDA is currently approved 

• Compounded gonadorelin is available through licensed compounding pharmacies where permitted 

Veterinary Use

An FDA-approved veterinary product (GONAbreed®) is available for reproductive disorders in cows and ovulation induction in rabbits . This is a prescription animal drug restricted to use by or on the order of a licensed veterinarian .

Research-Use Only

Gonadorelin acetate is available from research suppliers for in vitro and preclinical research use only. It is not for human consumption .

Reconstitution & Handling for Research

General Handling:

• Storage (Powder): -20°C (3 years) or 4°C (2 years) 

• Storage (Solution): -80°C (6 months) or -20°C (1 month) 

• Solubility: Soluble in water (25 mg/mL) and DMSO (≥12.5 mg/mL) 

• Shipping: Requires cold chain shipment for stability 

• Avoid Repeated Freeze-Thaw: Divide into aliquots to prevent degradation

Reference Standard: The USP Gonadorelin Acetate (2 mg) reference standard is available for pharmaceutical testing and assay use, with storage at -20°C .

Frequently Asked Questions

What is Gonadorelin Acetate?

Gonadorelin acetate is a synthetic decapeptide identical to endogenous GnRH that acts as a specific agonist for the GnRH receptor, stimulating LH and FSH release from the pituitary gland .

How does Gonadorelin Acetate work?

It binds to GnRH receptors in the anterior pituitary, triggering a signaling cascade that promotes the secretion of LH and FSH, which regulate reproductive function .

Is Gonadorelin FDA-approved?

No FDA-approved gonadorelin product is currently commercially available in the United States as of April 2026. Compounded gonadorelin is available through licensed compounding pharmacies where permitted .

What does research show about Gonadorelin Acetate?

In vitro research demonstrates inhibition of endometrial stem cell proliferation and migration. In vivo studies show reduced intestinal polyp multiplicity and colon tumor inhibition in mouse models. Clinical evidence supports pulsatile GnRH use in congenital hypogonadotropic hypogonadism .

Is there a veterinary version?

Yes. GONAbreed® is an FDA-approved prescription animal drug for reproductive disorders in cows and ovulation induction in rabbits .

What is the half-life of Gonadorelin?

Gonadorelin has a short half-life, requiring infusion pumps for clinical use .

Can I buy Gonadorelin Acetate?

Gonadorelin acetate is available from research suppliers for laboratory use only and as a USP reference standard for pharmaceutical testing . It is not legally marketed for human consumption.